Description

4,4',4''-Trimethyltrityl Alcohol is a specialized trityl-protected alcohol derivative, a crucial intermediate in advanced organic synthesis. Its primary value lies in its role as a versatile protecting group for hydroxyl functions, particularly in the synthesis of complex molecules like oligonucleotides, peptides, and pharmaceuticals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protecting group for the 5'-hydroxyl function in solid-phase DNA/RNA synthesis, enabling the controlled assembly of genetic material.
• Peptide Chemistry: Used for the temporary protection of serine, threonine, or tyrosine side chains during complex peptide assembly.
• Fine Chemical Synthesis: A critical reagent for the selective protection and deprotection steps in multi-step organic syntheses for agrochemicals and specialty chemicals.
• Material Science Research: Investigated as a monomer or precursor for developing novel polymers and dendritic structures with specific functionalities.
• Catalyst and Ligand Preparation: Utilized in the synthesis of sophisticated ligands for asymmetric catalysis and metal-organic frameworks.

Basic Information

Product Name	4,4',4''-Trimethyltrityl Alcohol
CAS No.	3247-00-5
Molecular Formula	C22H22O
Molecular Weight	302.41 g/mol
Synonyms	4,4',4''-Methylidynetris[benzenemethanol]; Tris(4-methylphenyl)methanol; 4,4',4''-Trimethyltritylol; TMT-OH; α,α,α-Tris(4-methylphenyl)methanol; Tris(p-tolyl)methanol; 4,4',4''-Trimethyltriphenylcarbinol; (4-Methylphenyl)diphenylmethanol (isomer).
EINECS	221-825-8

Quality Control

Our 4,4',4''-Trimethyltrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	168°C - 172°C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.