Description

Indolizine-2-Carboxylic Acid is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its unique fused bicyclic structure containing both pyrrole and pyridine-like nitrogen atoms makes it a valuable precursor for creating complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Serves as a core structure for designing new herbicides, fungicides, and insecticides with potential novel modes of action.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of organic semiconductors, dyes, and photochromic compounds due to its electron-rich aromatic system.
• Academic & Discovery Chemistry: A fundamental building block in heterocyclic and medicinal chemistry research for exploring new chemical space and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of complex natural product analogs and specialty chemicals.

Basic Information

Product Name	Indolizine-2-Carboxylic Acid
CAS No.	3189-48-8
Molecular Formula	C9H7NO2
Molecular Weight	161.16 g/mol
Synonyms	2-Indolizinecarboxylic Acid; 1-Aza-indene-2-carboxylic Acid; 2-Carboxyindolizine; Pyrrolo[1,2-a]pyridine-2-carboxylic Acid; Indolizine-2-carboxylic acid; 3189-48-8; 2-Indolizinecarboxylic acid; Pyrrolo[1,2-a]pyridine-2-carboxylic acid
EINECS	221-678-9

Quality Control

Our Indolizine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.