Description

Linolenic Acid, [9,12,15-1-14C] CAS NO 3131-67-7 is a carbon-14 labeled isotopologue of α-linolenic acid (ALA), an essential ω-3 fatty acid. This labeled compound is critical for metabolic and pharmacokinetic studies, enabling precise tracking and quantification in complex biological systems. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and agricultural chemical industries who require high-specific-activity tracers for advanced analytical applications.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the biosynthesis, elongation, and conversion of ω-3 fatty acids in vivo and in vitro.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies of lipid-based pharmaceuticals and nutraceuticals.
• Biochemical Research: Investigates the role of ALA in cell membrane fluidity, signaling pathways, and as a precursor to other bioactive lipids like EPA and DHA.
• Analytical Method Development: Serves as an internal standard for the development and validation of sensitive LC-MS/MS, GC-MS, and radio-HPLC methods.
• Agricultural & Nutritional Science: Tracks the incorporation and metabolism of essential fatty acids in crops, livestock, and feed formulations.
• Quality Control & Stability Testing: Used in pharmaceutical QC to study degradation pathways and validate the stability of ω-3 containing formulations.

Basic Information

Product Name	Linolenic Acid, [9,12,15-1-14C]
CAS No.	3131-67-7
Molecular Formula	C18H30O2 (with 14C label at position 1 of carbons 9, 12, and 15)
Molecular Weight	~278.43 g/mol (exact mass depends on specific activity)
Synonyms	(9Z,12Z,15Z)-9,12,15-Octadecatrienoic-1-14C Acid; α-Linolenic-1-14C Acid; ALA-1-14C; (Z,Z,Z)-9,12,15-Octadecatrienoic-1-14C Acid; 9,12,15-Octadecatrienoic-1-14C Acid, (all-Z)-; Linolenic Acid-1-14C; cis,cis,cis-9,12,15-Octadecatrienoic-1-14C Acid
EINECS	221-533-1 (for the unlabeled compound)

Quality Control

Every batch of Linolenic Acid, [9,12,15-1-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiolabeled compounds. Certificates of Analysis (COA) are provided, detailing specific activity (mCi/mmol or GBq/mmol), radiochemical purity (typically >97% by radio-HPLC or radio-TLC), chemical purity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C under an inert atmosphere (argon or nitrogen) to minimize oxidation. Avoid repeated freeze-thaw cycles. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow oil
Identification (IR / NMR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Contact for custom activity]
Radiochemical Purity (Radio-HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Toluene or Ethanol (specified on COA)
Concentration	0.1 mCi/mL (3.7 MBq/mL) [Custom concentrations available]

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.