Description

3-Fluoro-Thiophene is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is critical for introducing the thiophene scaffold with fluorine substitution, enabling precise modulation of electronic properties and lipophilicity in target molecules. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and solar cells.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying electrophilic aromatic substitution and other fluorination reactions in heterocyclic systems.
• Liquid Crystal and Dye Intermediate: Used to create fluorinated cores for high-performance liquid crystals and specialty dyes.

Basic Information

Product Name	3-Fluoro-Thiophene
CAS No.	3093-88-7
Molecular Formula	C4H3FS
Molecular Weight	102.13 g/mol
Synonyms	3-Fluorothiophene; Thiophene, 3-fluoro-; 3-Fluoro-1-thia-2,4-cyclopentadiene; 3-Fluorothiofuran; 3-FT; β-Fluorothiophene; m-Fluorothiophene
EINECS	221-428-3

Quality Control

Our 3-Fluoro-Thiophene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and away from heat sources and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.