Description

4,4',4''-Trimethoxytrityl Alcohol is a key trityl-protecting group reagent widely used in synthetic organic chemistry, particularly in oligonucleotide and peptide synthesis. Its primary value lies in its selective reactivity, enabling the protection of hydroxyl groups during complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity intermediates for the production of active pharmaceutical ingredients (APIs) and nucleic acid derivatives.

Application

• Oligonucleotide Synthesis: As a crucial protecting group for the 5'-hydroxyl function of nucleosides in phosphoramidite-based solid-phase synthesis.
• Peptide Synthesis: For the temporary protection of the hydroxyl side chains of serine, threonine, and tyrosine residues.
• Carbohydrate Chemistry: Employed in the selective protection of specific hydroxyl groups on sugar molecules during glycosylation reactions.
• Pharmaceutical Intermediates: Serves as a building block in the synthesis of complex drug molecules and diagnostic agents.
• Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel molecular entities.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring selective protection/deprotection strategies.

Basic Information

Product Name	4,4',4''-Trimethoxytrityl Alcohol
CAS No.	3010-81-9
Molecular Formula	C22H22O4
Molecular Weight	350.41 g/mol
Synonyms	MMT-OH; 4,4',4''-Trimethoxytrityl alcohol; Tris(4-methoxyphenyl)methanol; (4-Methoxyphenyl)bis(4-methoxyphenyl)methanol; α,α,α-Tris(4-methoxyphenyl)methanol; MMT Alcohol; Monomethoxytrityl Alcohol; 1,1',1''-(Hydroxytrimethylidyne)tris(4-methoxybenzene)
EINECS	221-131-8

Quality Control

Our 4,4',4''-Trimethoxytrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	156 - 160 °C
Loss on Drying	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.