Description

4-Fluoroisoquinoline is a versatile fluorinated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic introduction of a fluorine atom onto the isoquinoline scaffold, enabling precise modulation of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, including kinase inhibitors, receptor antagonists, and other biologically active molecules.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atom can enhance bioactivity and environmental persistence.
• Material Science Research: Serves as a precursor for developing fluorinated organic semiconductors, liquid crystals, and other functional materials.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological processes and enzyme mechanisms.
• Catalyst Ligand Development: The nitrogen and fluorine atoms provide a unique coordination environment for designing novel metal-organic catalysts.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and the effects of fluorine substitution on aromatic systems.

Basic Information

Product Name	4-Fluoroisoquinoline
CAS No.	394-67-2
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	Isoquinoline, 4-fluoro-; 4-Fluoro-isoquinoline; 4-Fluoro-2-azanaphthalene; 4-Fluoroisoquinoline; 394-67-2; 4-Fluoro-isoquinolin; 4-Fluoro-isoquinoline (ACI); 4-Fluoro-isoquinoline, 4-Fluoro-2-azanaphthalene
EINECS	206-902-5

Quality Control

Our 4-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.