Description

1-Fluoroisoquinoline is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis and pharmaceutical research. Its unique structure, featuring a fluorine atom on the isoquinoline scaffold, makes it a critical intermediate for introducing fluorine into complex molecules, thereby modulating their biological activity, metabolic stability, and physicochemical properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to create novel fluorinated pesticides and herbicides, where the fluorine atom can enhance bioavailability and environmental persistence.
• Material Science: Acts as a building block for developing specialty chemicals, liquid crystals, and organic electronic materials.
• Fluorination Chemistry Studies: Employed as a model substrate in methodological development for new fluorination and functionalization reactions.
• Ligand Synthesis: Utilized in the preparation of fluorinated ligands for catalysis and metal-organic frameworks (MOFs).
• Diagnostic Agent Development: Potential use in synthesizing fluorinated probes and tracers for imaging techniques like PET (Positron Emission Tomography).

Basic Information

Product Name	1-Fluoroisoquinoline
CAS No.	394-65-0
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	Isoquinoline, 1-fluoro-; 1-Fluoro-isoquinoline; 1-Fluoro-2-azanaphthalene; 394-65-0; NSC 406915; 1-Fluoroisoquinolin; Fluoroisoquinoline
EINECS	206-904-1

Quality Control

Our 1-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its fluoride/strong alkali reactivity profile, ensure proper segregation in storage areas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.