Description

2,2-Difluoropentanedioic Acid is a high-purity fluorinated dicarboxylic acid building block of significant interest in advanced organic synthesis. This compound matters for its unique ability to introduce fluorine atoms and a reactive diacid moiety into molecular frameworks, enabling the fine-tuning of physical, chemical, and biological properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other small molecule drugs where fluorine substitution enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators, leveraging fluorine's effect on lipophilicity and target binding.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Incorporated as a monomer or cross-linking agent to produce fluorinated polyesters, polyamides, and coatings with improved chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile building block in medicinal chemistry and material science for exploring structure-activity relationships (SAR) and developing new fluorinated compounds.

Basic Information

Product Name	2,2-Difluoropentanedioic Acid
CAS No.	380-86-9
Molecular Formula	C5H6F2O4
Molecular Weight	168.10 g/mol
Synonyms	2,2-Difluoroglutaric Acid; Difluoroglutaric Acid; Glutaric Acid, 2,2-Difluoro-; Pentanedioic Acid, 2,2-Difluoro-; 2,2-Difluoropentanedioic Acid; α,α-Difluoroglutaric Acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoropentanedioic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, assay, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which may affect product quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.