Description

α-(Trifluoromethyl)Benzhydrol is a versatile fluorinated organic intermediate characterized by its benzhydrol core structure and trifluoromethyl substituent. This compound is valued for its role in introducing the trifluoromethyl group into more complex molecules, a modification known to enhance metabolic stability, lipophilicity, and bioavailability in active pharmaceutical ingredients. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for use in synthesis, particularly in the development of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, where the trifluoromethyl group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic units.
• Organic Synthesis Reagent: Employed in academic and industrial R&D labs for constructing complex molecular architectures via reactions like nucleophilic addition or as a protecting group precursor.
• Fluorine Chemistry Studies: An important compound for investigating the unique reactivity and effects of the CF3 group in various chemical transformations.

Basic Information

Product Name	α-(Trifluoromethyl)Benzhydrol
CAS No.	379-18-0
Molecular Formula	C15H11F3O
Molecular Weight	264.24 g/mol
Synonyms	α-(Trifluoromethyl)benzhydrol; (Trifluoromethyl)diphenylmethanol; (Trifluoromethyl)diphenylcarbinol; Diphenyl(trifluoromethyl)methanol; Benzhydrol, α-(trifluoromethyl)-; 1,1,1-Trifluoro-2,2-diphenylethanol; 2,2-Diphenyl-1,1,1-trifluoroethanol
EINECS	206-809-5

Quality Control

Our α-(Trifluoromethyl)Benzhydrol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.