Description

1-Fluoro-4-Iodobutane is a versatile bifunctional alkyl halide building block of significant importance in advanced organic synthesis. Its molecular structure, featuring distinct fluoro and iodo termini, enables selective functionalization and chain extension, making it a critical reagent for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications ranging from nucleophilic substitution to cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in medicinal chemistry for introducing fluorinated alkyl chains.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and pesticides where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and advanced organic materials.
• Organic Synthesis Reagent: Employed in nucleophilic substitution reactions (SN2) where the iodo group is an excellent leaving group, and in cross-coupling reactions (e.g., Negishi, Kumada) for carbon-carbon bond formation.
• Fluorination Chemistry: Provides a source of a fluoroalkyl segment for further chemical transformations, useful in creating compounds with tailored physical and chemical properties.
• Chemical Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Item	Details
Product Name	1-Fluoro-4-Iodobutane
CAS No.	372-91-8
Molecular Formula	C4H8FI
Molecular Weight	202.01 g/mol
Synonyms	4-Fluoro-1-iodobutane; 1-Iodo-4-fluorobutane; Butane, 1-fluoro-4-iodo-; 4-Fluorobutyl iodide; ω-Fluoro-ω'-iodobutane; Fluorobutyl iodide; 4-Fluorobutane-1-iodide; 1-Fluorobutane-4-iodide
EINECS	206-756-4

Quality Control

Our 1-Fluoro-4-Iodobutane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to verify identity, purity, and moisture content. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in opaque secondary packaging.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.85 - 1.90 g/mL
Refractive Index (n20D)	1.495 - 1.505

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.