Description

1-Chloro-1-Fluorocyclohexane is a halogenated cycloalkane building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chlorine and fluorine substituents on the same carbon, makes it a valuable precursor for introducing fluorinated motifs into complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a key intermediate for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A versatile building block for synthesizing fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the introduction of fluorine atoms can enhance biological activity and environmental stability.
• Organic Synthesis Reagent: Acts as an electrophile in substitution reactions or as a starting material for preparing more complex fluorinated and chlorinated cyclic compounds.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where the cyclohexane ring with halogen substituents can modify physical properties.
• Fluorine Chemistry Studies: Serves as a model substrate in academic and industrial research to study reaction mechanisms and stability of gem-dihalo compounds.

Basic Information

Product Name	1-Chloro-1-Fluorocyclohexane
CAS No.	371-89-1
Molecular Formula	C6H10ClF
Molecular Weight	136.59 g/mol
Synonyms	Cyclohexane, 1-chloro-1-fluoro-; 1-Chloro-1-fluorocyclohexane; 1-Fluoro-1-chlorocyclohexane; Chlorofluorocyclohexane; (Chlorofluoro)cyclohexane; NSC 3775; 371-89-1
EINECS	206-742-9

Quality Control

Our 1-Chloro-1-Fluorocyclohexane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our commitment to consistent quality and traceability supports your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reactive metals. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.10 - 1.20 g/mL
Refractive Index (n20D)	1.450 - 1.460

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.