Description

Tris(2,2,2-trifluoroethyl) phosphite is a specialized organophosphorus compound characterized by its trifluoroethoxy substituents. This structure is critical for its role as a high-performance intermediate and ligand in advanced chemical synthesis, offering unique reactivity and stability profiles. It is primarily sought after by manufacturers and research institutions in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel compounds and catalytic systems.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated components for enhanced metabolic stability and bioavailability.
• Ligand for Catalysis: Serves as a ligand in transition metal-catalyzed reactions, including cross-coupling and hydrogenation, where its electron-withdrawing groups can modulate catalyst activity.
• Agrochemical Synthesis: A key building block for creating advanced pesticides and herbicides with improved efficacy and environmental profiles.
• Polymer Modification: Employed as a stabilizer or co-monomer in the production of high-performance fluoropolymers and specialty plastics.
• Flame Retardant Formulations: Acts as a synergistic component in flame-retardant systems for electronics and construction materials.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new organophosphorus chemistry and material science applications.

Basic Information

Product Name	Tris(2,2,2-trifluoroethyl) phosphite
CAS No.	370-69-4
Molecular Formula	C6H6F9O3P
Molecular Weight	328.08 g/mol
Synonyms	Phosphorous acid, tris(2,2,2-trifluoroethyl) ester; Tris(2,2,2-trifluoroethoxy)phosphine; 2,2,2-Trifluoroethyl phosphite; Tris(β,β,β-trifluoroethyl) phosphite; Tris(perfluoroethyl) phosphite; TTFEP; (CF3CH2O)3P
EINECS	206-736-7

Quality Control

Our Tris(2,2,2-trifluoroethyl) phosphite is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is easily oxidized; for long-term storage, maintaining an inert atmosphere (nitrogen or argon) is recommended. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (20°C)	~1.55 g/cm³
Refractive Index (n20D)	~1.335

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.