Description

5-Iodo-1,1,1-Trifluoropentane is a halogenated alkane building block of significant interest in advanced organic synthesis. Its unique structure, featuring both iodine and fluorine substituents, makes it a versatile intermediate for introducing functional complexity into target molecules. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of fluorinated drug candidates, leveraging the iodine atom for further cross-coupling reactions and the trifluoromethyl group for modulating bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Material Science Precursor: Acts as a monomer or modifying agent in the development of specialty polymers and coatings with unique surface properties, such as oil and water repellency.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display technologies, contributing to improved performance and stability.
• Cross-Coupling Reactions: The iodine atom makes it a suitable substrate for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to form carbon-carbon bonds, a fundamental step in complex molecule assembly.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying structure-activity relationships and developing new fluorination methodologies.

Basic Information

Product Name	5-Iodo-1,1,1-Trifluoropentane
CAS No.	352-60-3
Molecular Formula	C5H8F3I
Molecular Weight	252.02 g/mol
Synonyms	1,1,1-Trifluoro-5-iodopentane; 5-Iodo-1,1,1-trifluoropentane; 1-Iodo-5,5,5-trifluoropentane; Pentane, 5-iodo-1,1,1-trifluoro-; ω-Iodo-1,1,1-trifluoropentane; 5,5,5-Trifluoro-1-iodopentane; Iodopentafluoropropane (related class); TFIP (abbrev.)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting all critical parameters are available upon request. Our quality management system supports the needs of research and development as well as scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place, away from strong acids and organic solvents. Recommended storage temperature is between 2°C and 8°C for extended stability, although short-term storage at controlled room temperature (15-25°C) is acceptable. Keep container tightly sealed when not in use to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%
Density (at 20°C)	~1.8 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.