Description

Ethyl 4,4-Difluoro-3-Oxobutanoate is a versatile fluorinated β-keto ester building block, prized for its unique reactivity profile. Its molecular structure, featuring both a reactive carbonyl and a difluoromethylene group, makes it a critical intermediate for synthesizing complex fluorinated molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where the introduction of fluorine atoms is a key strategy for modulating the biological activity, metabolic stability, and lipophilicity of target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to construct fluorinated heterocycles and active components in advanced herbicides, fungicides, and insecticides, enhancing their efficacy and environmental profile.
• Material Science: Serves as a monomer or building block for creating fluorinated polymers and specialty materials with enhanced chemical resistance, thermal stability, or unique surface properties.
• Organic Synthesis & Research: Employed in Claisen condensations, Michael additions, and cyclization reactions to access fluorinated pyrazoles, isoxazoles, and other valuable heterocyclic scaffolds.
• Liquid Crystal & Electronic Chemicals: Acts as a starting material for synthesizing fluorinated liquid crystal compounds and other electronic chemicals used in display technologies.

Basic Information

Item	Details
Product Name	Ethyl 4,4-Difluoro-3-Oxobutanoate
CAS No.	352-24-9
Molecular Formula	C6H8F2O3
Molecular Weight	166.12 g/mol
Synonyms	Ethyl 4,4-Difluoroacetoacetate; 4,4-Difluoro-3-oxobutanoic Acid Ethyl Ester; Ethyl 4,4-Difluoro-3-oxobutyrate; Difluoroacetoacetic Acid Ethyl Ester; Ethyl Difluoroacetoacetate; 3-Oxo-4,4-difluorobutanoic Acid Ethyl Ester; EDFA; 352-24-9
EINECS	206-524-4

Quality Control

Our Ethyl 4,4-Difluoro-3-Oxobutanoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.