Description

Ethyl 6-(Trifluoromethyl)-Indole-2-Carboxylate is a high-value fluorinated indole derivative, a crucial synthetic intermediate in advanced organic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, enhancing their biological activity and physicochemical profile. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it serves as a key building block for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the CF3 group improves lipophilicity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials with tailored properties.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in the study of enzyme mechanisms and protein interactions due to its distinctive spectroscopic signature.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and medicinal chemistry programs in university and CRO laboratories.

Basic Information

Product Name	Ethyl 6-(Trifluoromethyl)-Indole-2-Carboxylate
CAS No.	327-21-9
Molecular Formula	C12H10F3NO2
Molecular Weight	257.21 g/mol
Synonyms	Ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate; 6-(Trifluoromethyl)-1H-indole-2-carboxylic Acid Ethyl Ester; 2-Carbethoxy-6-trifluoromethylindole; Ethyl 6-Trifluoromethylindole-2-Carboxylate; 1H-Indole-2-carboxylic acid, 6-(trifluoromethyl)-, ethyl ester; 327-21-9; Ethyl α-Carboxy-6-trifluoromethylindole
EINECS	Contact for details

Quality Control

Our production of Ethyl 6-(Trifluoromethyl)-Indole-2-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.