Description

6-Trifluoromethyl-1H-Indole-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block prized for its unique trifluoromethyl-substituted indole scaffold. This compound is essential for medicinal chemistry research and development, offering a strategic handle for modulating the physicochemical and pharmacokinetic properties of target molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drugs targeting various therapeutic areas, including oncology, CNS disorders, and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functional organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	6-Trifluoromethyl-1H-Indole-2-Carboxylic Acid
CAS No.	327-20-8
Molecular Formula	C10H6F3NO2
Molecular Weight	229.16 g/mol
Synonyms	2-Carboxy-6-(trifluoromethyl)indole; 6-(Trifluoromethyl)-1H-indole-2-carboxylic acid; 6-Trifluoromethylindole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 6-(trifluoromethyl)-; 6-Trifluoromethyl-1H-indol-2-carbonsäure (German); Acide 6-trifluorométhyl-1H-indole-2-carboxylique (French)
EINECS	Contact for details

Quality Control

Our production of 6-Trifluoromethyl-1H-Indole-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch and supplied upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.