Description

(+)Ephedrine Hemihydrate CAS NO 321-98-2 is a high-purity, enantiomerically pure alkaloid widely recognized for its potent sympathomimetic activity. This compound is a critical chiral intermediate and active pharmaceutical ingredient (API) essential for ensuring precise pharmacological effects in final formulations. It is primarily required by the pharmaceutical industry for the synthesis of decongestants, bronchodilators, and other therapeutic agents, as well as by research institutions for biochemical studies and analytical standard preparation.

Application

• Pharmaceutical API: Key intermediate and active ingredient in the manufacture of prescription and over-the-counter (OTC) decongestant and bronchodilator medications.
• Chemical Synthesis: Serves as a crucial chiral building block for the synthesis of more complex pharmaceutical compounds and fine chemicals.
• Analytical Standard: Used as a certified reference material (CRM) in HPLC, GC, and other analytical methods for quality control and regulatory testing.
• Biochemical Research: Employed in pharmacological and neuroscience research to study adrenergic receptor mechanisms and physiological responses.
• Veterinary Medicine: Utilized in formulations for treating respiratory conditions in animals.

Basic Information

Product Name	(+)Ephedrine Hemihydrate
CAS No.	321-98-2
Molecular Formula	C10H15NO · ½H2O
Molecular Weight	174.24 g/mol (anhydrous basis)
Synonyms	(1R,2S)-(-)-Ephedrine Hemihydrate; l-Ephedrine Hemihydrate; (-)-Ephedrine Hemihydrate; Ephedrine (USP); Ephoxamin; Isofedrol; 2-Methylamino-1-phenylpropan-1-ol Hemihydrate; Sanedrine
EINECS	206-275-0

Quality Control

Our (+)Ephedrine Hemihydrate is manufactured under strict quality management systems. Each batch is tested to meet or exceed relevant pharmacopeial standards such as USP and EP. Comprehensive testing includes chiral purity, assay, and impurity profiling to ensure batch-to-batch consistency and regulatory compliance. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation [α]20/D	-33° to -36° (c=5 in H2O)
Water Content (KF)	4.0% - 5.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.