Description

Ethyl 4-Trifluoromethylindole-2-Carboxylate is a high-value fluorinated indole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity and electronic properties imparted by the trifluoromethyl group, enabling the development of novel compounds with enhanced biological activity and metabolic stability. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Development: Used to construct advanced active ingredients for crop protection agents, leveraging the trifluoromethyl group to improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags and molecular probes for studying biological pathways.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in medicinal chemistry and heterocyclic chemistry research.

Basic Information

Product Name	Ethyl 4-Trifluoromethylindole-2-Carboxylate
CAS No.	317-60-2
Molecular Formula	C₁₂H₁₀F₃NO₂
Molecular Weight	257.21 g/mol
Synonyms	Ethyl 4-(Trifluoromethyl)-1H-indole-2-carboxylate; 4-Trifluoromethylindole-2-carboxylic Acid Ethyl Ester; 2-Carbethoxy-4-trifluoromethylindole; 1H-Indole-2-carboxylic acid, 4-(trifluoromethyl)-, ethyl ester; Ethyl 4-trifluoromethyl-1H-indole-2-carboxylate; 4-(Trifluoromethyl)indole-2-carboxylic acid ethyl ester
EINECS	206-262-7

Quality Control

Our Ethyl 4-Trifluoromethylindole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.