Description

4-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its indole core and trifluoromethyl substituent. This compound is essential for medicinal chemistry and agrochemical research, where its unique structure enables the fine-tuning of molecular properties such as lipophilicity, metabolic stability, and binding affinity. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for developing potential drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the indole scaffold.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated properties.
• Biochemical Tool Compound: Employed in academic and industrial research to study enzyme inhibition and probe biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom chemical synthesis services targeting complex, fluorinated molecules.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid
CAS No.	317-59-9
Molecular Formula	C10H6F3NO2
Molecular Weight	229.16 g/mol
Synonyms	4-(Trifluoromethyl)-1H-indole-2-carboxylic acid; 2-Carboxy-4-(trifluoromethyl)indole; 4-Trifluoromethylindole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 4-(trifluoromethyl)-; α-Carboxy-4-(trifluoromethyl)indole; 4-(Trifluoromethyl)indole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethyl)-1H-Indole-2-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the exacting standards required for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.