Description

Aminophylline CAS NO 317-34-0 is a complex of theophylline and ethylenediamine, widely recognized for its bronchodilator and respiratory stimulant properties. This compound is a critical active pharmaceutical ingredient (API) essential for formulating reliable and effective therapeutic products. It is primarily required by the pharmaceutical industry for the manufacture of medications targeting respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and apnea of prematurity.

Application

• Pharmaceutical API: Primary use as the active ingredient in bronchodilator medications for asthma and COPD.
• Respiratory Stimulant: Formulation of injectable solutions and oral medications for treating apnea and bradycardia in neonates.
• Cardiac Medication: Used as an adjunct therapy for acute heart failure due to its positive inotropic and chronotropic effects.
• Veterinary Medicine: Application in veterinary pharmaceuticals for treating bronchospasm in animals.
• Research & Development: Serves as a reference standard and key reagent in pharmacological and biochemical research.
• Generic Drug Manufacturing: Essential for producing cost-effective generic versions of branded aminophylline drugs.

Basic Information

Product Name	Aminophylline
CAS No.	317-34-0
Molecular Formula	C16H24N10O4
Molecular Weight	420.42 g/mol
Synonyms	Aminophylline Hydrate; Theophylline Ethylenediamine; Theophylline Ethylenediamine Complex; Euphyllin; Metaphyllin; Cardophyllin; Phyllocontin; Aminodur; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione compound with 1,2-ethanediamine (2:1)
EINECS	206-264-5

Quality Control

Our Aminophylline is manufactured under strict quality management systems. Each batch is tested to ensure compliance with major pharmacopeial standards, including USP, EP, and BP monographs. Key parameters such as identification, assay, related substances, and residual solvents are rigorously controlled. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or slightly yellowish crystalline powder
Identification (IR)	Conforms to standard
Identification (Theophylline)	Conforms to standard
Identification (Ethylenediamine)	Conforms to standard
Assay (Anhydrous Basis)	84.0% - 87.4% (as Theophylline)
Water Content (Karl Fischer)	NMT 0.75%
Related Substances (HPLC)	Total impurities NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.