Description

2-(Trifluoromethyl)Benzimidazole is a high-purity, fluorinated heterocyclic compound serving as a critical building block in advanced chemical synthesis. Its value lies in the unique properties imparted by the trifluoromethyl group, which enhances metabolic stability, lipophilicity, and bioavailability in target molecules. This intermediate is essential for research and production in the pharmaceutical and agrochemical industries, particularly for developing active ingredients with improved performance profiles.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides, herbicides, and fungicides where the trifluoromethyl group contributes to efficacy and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated components.
• Biochemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and high-throughput screening.
• Coordination Chemistry: Acts as a ligand for metal complexes used in catalysis and imaging applications.

Basic Information

Product Name	2-(Trifluoromethyl)Benzimidazole
CAS No.	312-73-2
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	2-(Trifluoromethyl)-1H-benzimidazole; 1H-Benzimidazole, 2-(trifluoromethyl)-; α,α,α-Trifluoro-2-benzimidazole; 2-Trifluoromethylbenzimidazole; 2-TFMBI; Benzimidazole, 2-trifluoromethyl-; NSC 404087; 2-(Trifluoromethyl)-1H-benzo[d]imidazole
EINECS	206-227-5

Quality Control

Our 2-(Trifluoromethyl)Benzimidazole is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for each shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.