Description

2,6-Piperidinedione, 3-[1,3-Dihydro-6-(Hydroxymethyl)-1-Oxo-2H-Isoindol-2-Yl]- is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly those targeting specific biological pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including potential oncology and neurology treatments.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Proteasome Inhibitor Research: Used in the research and development of compounds targeting the ubiquitin-proteasome pathway.
• Oncology Drug Discovery: Serves as a precursor in the creation of potential anti-cancer agents and targeted therapies.
• Neurological Disorder Research: Applied in the synthesis of compounds being studied for neurodegenerative diseases.
• Chemical Biology & Proteomics: Utilized as a tool compound or tag in studying protein function and interaction.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial manufacturing of complex drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2,6-Piperidinedione, 3-[1,3-Dihydro-6-(Hydroxymethyl)-1-Oxo-2H-Isoindol-2-Yl]-
CAS No.	2803882-16-6
Molecular Formula	C14H14N2O4
Molecular Weight	274.27 g/mol
Synonyms	3-(1,3-Dihydro-6-(hydroxymethyl)-1-oxo-2H-isoindol-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-(1,3-dihydro-6-(hydroxymethyl)-1-oxo-2H-isoindol-2-yl)-; 3-(1,3-Dihydro-6-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 6-(Hydroxymethyl)thalidomide analog; Hydroxymethyl-thalidomide derivative; Isoindolinone-piperidinedione conjugate; Proteasome inhibitor intermediate
EINECS	Contact for details

Quality Control

Our 2,6-Piperidinedione derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.