Description

Isoquinoline, 1-[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]- is a high-purity, chiral organic compound featuring a complex molecular architecture that combines isoquinoline and oxazoline pharmacophores. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of novel chemical entities with specific stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and specialized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and anti-infective drug candidates.
• Asymmetric Catalysis: Serves as a precursor for the synthesis of chiral oxazoline-based ligands used in metal-catalyzed asymmetric transformations.
• Agrochemical Synthesis: An intermediate in the production of advanced, stereospecific pesticides and herbicides.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and other functional organic materials.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	Isoquinoline, 1-[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-
CAS No.	2757083-35-3
Molecular Formula	C19H18N2O
Molecular Weight	290.36 g/mol
Synonyms	(R)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole; 1-[(4R)-4-Benzyl-4,5-dihydro-1,3-oxazol-2-yl]isoquinoline; (R)-1-(4-Benzyl-4,5-dihydrooxazol-2-yl)isoquinoline; (4R)-4-Benzyl-2-(1-isoquinolyl)-4,5-dihydrooxazole; Chiral Isoquinoline-Oxazoline Ligand Precursor; (R)-BIQO; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Isoquinoline, 1-[(4R)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (assay), chiral excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.