Description

Isoquinoline, 1-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]- is a chiral, heterocyclic organic compound featuring a fused isoquinoline-oxazoline scaffold. This molecule is of significant commercial interest as a key chiral building block and ligand precursor in asymmetric synthesis and pharmaceutical research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Asymmetric Catalysis: Acts as a precursor for the synthesis of chiral oxazoline-based ligands used in metal-catalyzed asymmetric transformations (e.g., hydrogenation, cyclopropanation).
• Agrochemical Research: Employed in the development of novel, enantiomerically pure pesticides and herbicides where specific stereochemistry is crucial for bioactivity.
• Material Science: Investigated as a monomer or functional unit for creating chiral polymers and advanced organic materials with specific optical properties.
• Academic & Contract Research: Used in university and CRO (Contract Research Organization) settings for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Isoquinoline, 1-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-
CAS No.	2757083-34-2
Molecular Formula	C18H16N2O
Molecular Weight	276.33 g/mol
Synonyms	(R)-4-Phenyl-4,5-dihydro-2-(isoquinolin-1-yl)oxazole; 1-[(4R)-4,5-Dihydro-4-phenyl-1,3-oxazol-2-yl]isoquinoline; (R)-1-(4-Phenyl-4,5-dihydrooxazol-2-yl)isoquinoline; Chiral Isoquinoline-Oxazoline Ligand Precursor; (R)-PQOX; (R)-Isoquinolinyl Oxazoline
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including Chiral HPLC, 1H/13C NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity (enantiomeric excess), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.