Description

Milrinone-D3 is a deuterated isotopologue of the phosphodiesterase 3 inhibitor Milrinone, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Milrinone in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research sectors, ensuring data integrity in pharmacokinetic studies, bioequivalence testing, and therapeutic drug monitoring.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the LC-MS/MS quantification of Milrinone in plasma, serum, and other biological fluids.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion in clinical and non-clinical studies.
• Drug Metabolism Studies: Used in mass spectrometry to differentiate between the drug and its metabolites, facilitating metabolic pathway elucidation.
• Bioequivalence Testing: Critical for ensuring analytical method accuracy when comparing generic and innovator drug formulations.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring Milrinone levels in patient samples.
• Quality Control in Pharmaceutical Manufacturing: Used in analytical method development and validation to ensure the specificity and accuracy of potency assays.

Basic Information

Product Name	Milrinone-D3
CAS No.	2749393-50-6
Molecular Formula	C12H6D3N3O
Molecular Weight	214.23 g/mol
Synonyms	1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile-d3; 2-Methyl-5-cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]-d3; Milrinone (methyl-d3); [2H3]-Milrinone; Milrinone Internal Standard; Milrinone-d3 (methyl-d3); WIN 47203-d3
EINECS	Contact for details

Quality Control

Our Milrinone-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive mass spectrometry applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and LC-MS to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results for assay, isotopic purity, and solvent residues, supporting compliance with GLP and GMP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 99.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.