Description

Loratadine-D4 is a deuterium-labeled analog of the widely used antihistamine, loratadine, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is a critical material for pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control units requiring precise and validated analytical methods.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of loratadine and its metabolites in biological matrices.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the metabolic pathways of loratadine.
• Quality Control and Method Validation: Serves as a critical component in the development and validation of robust analytical methods for pharmaceutical quality assurance.
• Forensic and Anti-Doping Analysis: Supports accurate quantification in specialized testing environments where precise measurement of antihistamines is required.
• Reference Material for Certified Standards: Acts as a precursor or component in the preparation of certified reference materials (CRMs) for regulatory compliance.

Basic Information

Product Name	Loratadine-D4
CAS No.	2748435-73-4
Molecular Formula	C22H19D4ClN2O2
Molecular Weight	382.90 g/mol (for C22H19D4ClN2O2)
Synonyms	Loratadine-d4; Deuterated Loratadine; 8-Chloro-6,11-dihydro-11-(1-[(2H4)methyl]-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-(methyl-d4)piperidinecarboxylate; Claritin-D4; SCH 29851-D4
EINECS	Contact for details

Quality Control

Our Loratadine-D4 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is fully characterized and supplied with a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and confirmation of structure. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.