Description

1H-Isoindole-1,3(2H)-Dione, 4-Bromo-2-(2,6-Dioxo-3-Piperidinyl)-7-Fluoro- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel therapeutic agents. This compound is critical for medicinal chemistry research and development, particularly in the creation of targeted small-molecule drugs. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology and immunology pipelines.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of Proteolysis Targeting Chimeras (PROTACs) and other targeted protein degraders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for developing new chemical entities (NCEs).
• Oncology Drug Discovery: Serves as a core scaffold in the development of inhibitors and degraders for cancer-related protein targets.
• Chemical Biology Probes: Employed in the creation of molecular tools for studying intracellular protein function and degradation pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and drug mechanism studies.

Basic Information

Product Name	1H-Isoindole-1,3(2H)-Dione, 4-Bromo-2-(2,6-Dioxo-3-Piperidinyl)-7-Fluoro-
CAS No.	2740657-30-9
Molecular Formula	C13H8BrFN2O4
Molecular Weight	355.12 g/mol
Synonyms	4-Bromo-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione; 7-Fluoro-4-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-Bromo-7-fluoro-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; Thalidomide-based PROTAC linker; Bromo-fluoro glutarimide derivative; Fluorinated cereblon ligand intermediate; E3 ligase ligand building block.
EINECS	Contact for details

Quality Control

Our 1H-Isoindole-1,3(2H)-Dione, 4-Bromo-2-(2,6-Dioxo-3-Piperidinyl)-7-Fluoro- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.