Description

Metolazone-D7 is a high-purity, deuterium-labeled internal standard essential for accurate quantitative analysis in advanced research and development. This stable isotope-labeled compound is critical for ensuring precision and reliability in mass spectrometry-based analytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in method development and quality control for drug substances.

Application

• Internal standard for the quantitative analysis of Metolazone and its metabolites using Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Use in pharmacokinetic studies to track drug absorption, distribution, metabolism, and excretion (ADME) with high precision.
• Critical component in bioanalytical method development and validation for regulatory submissions.
• Application in clinical research for accurate therapeutic drug monitoring (TDM).
• Utilization in forensic and anti-doping analysis for definitive identification and quantification.
• Supporting research into the metabolic pathways and stability of thiazide-like diuretics.

Basic Information

Item	Detail
Product Name	Metolazone-D7
CAS No.	2714484-71-4
Molecular Formula	C16H9D7ClN2O3S
Molecular Weight	~369.85 g/mol
Synonyms	7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-(o-tolyl)-3-oxo-6-quinazolinesulfonamide-D7; Metolazone (methyl-D3, phenyl-D4); Deuterated Metolazone; Metolazone-d7; [D7]-Metolazone; 2-Methyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-(o-tolyl)quinazolin-3-one-D7; Zaroxolyn-D7 (labeled)
EINECS	Contact for details

Quality Control

Every batch of Metolazone-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.