Description

8-(Trifluoromethyl)Isoquinolin-4-Amine is a high-value, fluorinated isoquinoline derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring a reactive amine group and a stable trifluoromethyl moiety, makes it indispensable for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology: Employed as a molecular probe or tag in biochemical research due to its distinct fluorine signature for NMR studies.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel nitrogen-containing ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	8-(Trifluoromethyl)Isoquinolin-4-Amine
CAS No.	2708281-64-3
Molecular Formula	C10H7F3N2
Molecular Weight	212.17 g/mol
Synonyms	4-Amino-8-(trifluoromethyl)isoquinoline; 8-(Trifluoromethyl)-4-isoquinolinamine; 8-Trifluoromethylisoquinolin-4-ylamine; 4-Isoquinolinamine, 8-(trifluoromethyl)-; 2708281-64-3; 8-CF3-Isoquinolin-4-amine
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl)Isoquinolin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.