Description

1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-Methoxy-, 2-(1,1-Dimethylethyl) Ester, (1R)- is a high-purity, chiral isoquinoline derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for pharmaceutical research and development, offering a complex, stereodefined scaffold. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for creating novel active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular diseases.
• Advanced Organic Synthesis: Serves as a versatile building block for constructing polycyclic and heterocyclic frameworks in medicinal chemistry programs.
• Asymmetric Catalysis Research: Used in the development and study of new chiral ligands and catalysts due to its rigid, stereogenic structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of high-value target molecules.
• Academic Research: A valuable reagent for university and institutional research in synthetic methodology and total synthesis projects.

Basic Information

Product Name	1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-Methoxy-, 2-(1,1-Dimethylethyl) Ester, (1R)-
CAS No.	2703746-30-7
Molecular Formula	C17H21NO5
Molecular Weight	319.35 g/mol
Synonyms	(1R)-2-(tert-Butyl) 3,4-dihydro-6-methoxy-1H-isoquinoline-1,2(2H)-dicarboxylate; (1R)-2-tert-Butyl 3,4-dihydro-6-methoxyisoquinoline-1,2(1H,2H)-dicarboxylate; (R)-2-(tert-Butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-6-methoxy-, 2-(1,1-dimethylethyl) ester, (R)-; (R)-2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; (R)-6-Methoxy-2-Boc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; Chiral Isoquinoline Building Block
EINECS	Contact for details

Quality Control

Our 1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-Methoxy-, 2-(1,1-Dimethylethyl) Ester, (1R)- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. All materials are subjected to comprehensive analytical testing, including HPLC for assay and impurity profiling, chiral analysis to confirm enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.