Description

(R)-6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Asymmetric Synthesis: Used in the construction of enantiomerically pure tetrahydroisoquinoline scaffolds, which are prevalent in bioactive molecules.
• Medicinal Chemistry Research: Serves as a critical starting material or intermediate in lead optimization and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-up: Employed in the development and optimization of commercial-scale synthetic routes for API manufacturing.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	(R)-6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Hydrochloride
CAS No.	2703745-93-9
Molecular Formula	C11H14ClNO3
Molecular Weight	243.69 g/mol
Synonyms	(R)-6-Methoxy-1,2,3,4-tetrahydro-1-isoquinolinecarboxylic acid hydrochloride; (1R)-6-Methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride; (R)-6-Methoxy-Tic-OH.HCl; (R)-MTIQ; (R)-6-OMe-Tic-OH.HCl; (R)-1-Carboxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.