Description

1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-Methoxy-, 2-(1,1-Dimethylethyl) Ester, (1S)- is a high-purity, chiral isoquinoline derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block or key chiral intermediate for the development of complex molecules, particularly in the pharmaceutical sector. It is primarily needed by research institutions and chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) or anti-cancer targets.
• Agrochemical Research: Used in the development of advanced, stereospecific pesticides and herbicides where the specific enantiomer can influence biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation or other catalytic transformations.
• Fine Chemical Synthesis: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks with defined stereochemistry.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in regulatory filings.

Basic Information

Product Name	1,2(1H)-Isoquinolinedicarboxylic Acid, 3,4-Dihydro-6-Methoxy-, 2-(1,1-Dimethylethyl) Ester, (1S)-
CAS No.	2703745-74-6
Molecular Formula	C17H21NO5
Molecular Weight	319.35 g/mol
Synonyms	(1S)-2-(tert-Butyl) 3,4-dihydro-6-methoxy-1H-isoquinoline-1,2(2H)-dicarboxylate; (1S)-2-tert-Butyl 3,4-dihydro-6-methoxyisoquinoline-1,2(1H,2H)-dicarboxylate; (S)-2-(tert-Butoxycarbonyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 1,2(1H)-Isoquinolinedicarboxylic acid, 3,4-dihydro-6-methoxy-, 2-(1,1-dimethylethyl) ester, (1S)-; (S)-2-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2703745-74-6; (S)-2-(tert-Butyl) 6-methoxy-3,4-dihydro-1H-isoquinoline-1,2(2H)-dicarboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized using advanced analytical techniques including HPLC, chiral HPLC, GC, NMR, and MS to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is likely moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.