Description

Tetrabenazine-D7 is a deuterated analog of the vesicular monoamine transporter 2 (VMAT2) inhibitor, Tetrabenazine, where seven hydrogen atoms are replaced with the stable isotope deuterium. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in the development and bioanalysis of central nervous system (CNS) therapeutics.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Tetrabenazine and its metabolites in biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioanalytical Method Development and Validation: Serves as a reference standard to establish selective, sensitive, and robust analytical assays compliant with FDA and ICH guidelines.
• Clinical Trial Support: Used in the bioanalysis phase of clinical trials to ensure data integrity for regulatory submissions.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques to minimize matrix effects and ionization variability.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex samples.

Basic Information

Product Name	Tetrabenazine-D7
CAS No.	2701977-99-1
Molecular Formula	C19H20D7NO3
Molecular Weight	323.5 g/mol (approx.)
Synonyms	TBZ-D7; Deutetrabenazine-D7 (heptadeutero); 1,3,4,6,7,11b,13-Heptadeutero-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one; Nitoman-D7; Xenazine-D7; RO 1-9569-D7; Deuterated Tetrabenazine (D7)
EINECS	Contact for details

Quality Control

Our Tetrabenazine-D7 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical purity (HPLC), isotopic enrichment (NMR/MS), and residual solvents. We adhere to relevant industry standards for reference materials, supporting GLP/GMP-compliant research. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98.0 atom % D
Chemical Purity (by HPLC)	≥99.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.