Description

(+)-Nebivolol-D4 Hydrochloride CAS NO 2701283-32-9 is a deuterated isotopologue of the β-blocker Nebivolol, specifically labeled with four deuterium atoms, and is supplied as the hydrochloride salt. This compound is an essential internal standard for the precise and accurate quantification of Nebivolol in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical R&D, clinical research, and bioanalytical laboratories focused on pharmacokinetic studies, drug metabolism research, and ensuring regulatory compliance in drug development.

Application

• Bioanalytical Reference Standard: Serves as a stable isotope-labeled internal standard for the quantification of Nebivolol in plasma, serum, and other biological fluids via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling: Used in method development and validation to identify and quantify related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Forensic & Clinical Toxicology: Supports accurate assay development for the detection and measurement of Nebivolol in forensic and diagnostic applications.
• Pharmaceutical Quality Control: Critical for ensuring the accuracy and reliability of analytical methods used in the quality assurance of Nebivolol-based drug products.
• Regulatory Submissions: Provides the necessary data integrity and method validation support required for filings with agencies like the FDA and EMA.

Basic Information

Product Name	(+)-Nebivolol-D4 Hydrochloride
CAS No.	2701283-32-9
Molecular Formula	C22H21D4F2NO4 • HCl
Molecular Weight	441.92 g/mol (for free base C22H21D4F2NO4)
Synonyms	Nebivolol D4 HCl; Nebivolol-d4 Hydrochloride; (1RS,1'RS)-1,1'-[(2RS,2'SR)-Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol-d4 Hydrochloride; 1,1'-[Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol-d4 Hydrochloride; BRL-35113A-d4; R-65824-d4; (SRRR)-Nebivolol-d4 HCl; Deuterated Nebivolol HCl
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment (D4), chemical purity, and identification data, supporting GMP/GLP-compliant research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isotopic Purity (MS)	≥98.0 atom % D (D4)
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.