Description

n-Arachidonoyl-L-Serine-D8 is a deuterated analog of the endogenous endocannabinoid-like lipid mediator, n-arachidonoyl-L-serine. This compound is of significant value for research and development, particularly in analytical chemistry and pharmacology, where it serves as a critical internal standard for mass spectrometry. It enables precise quantification and metabolic tracing of its non-deuterated counterpart in complex biological matrices. This high-purity standard is essential for scientists in pharmaceutical R&D, academic research, and contract testing laboratories focused on the endocannabinoid system and lipid signaling pathways.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the accurate quantification of n-arachidonoyl-L-serine in bioanalytical studies.
• Metabolic Pathway Research: Used as a tracer to study the biosynthesis, distribution, and degradation pathways of endocannabinoid-like lipids in vitro and in vivo.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Critical for determining the absorption, distribution, metabolism, and excretion (ADME) profiles of related compounds in preclinical development.
• Method Development and Validation: Employed in the development and validation of highly sensitive and specific analytical methods in compliance with GLP guidelines.
• Biomarker Discovery and Analysis: Facilitates the precise measurement of lipid mediators in clinical samples for biomarker research related to neurological and inflammatory conditions.
• Quality Control Reference: Serves as a certified reference material (CRM) for quality assurance in the production and analysis of high-value lipid-based pharmaceuticals or research chemicals.

Basic Information

Product Name	n-Arachidonoyl-L-Serine-D8
CAS No.	2699607-45-7
Molecular Formula	C₂₃H₂₅D₈NO₄
Molecular Weight	403.6 g/mol (approx.)
Synonyms	ARA-S-D8; N-Arachidonoyl-L-serine-d8; Deuterated n-Arachidonoyl Serine; (2S)-2-[(1R,5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraenamido]-3-hydroxypropanoic-1,1,2,3,3-d5 Acid; 20:4 N-Acyl Serine-D8; N-Docosatetraenoyl-L-serine-D8; Endocannabinoid-like Lipid Standard-D8
EINECS	Contact for details

Quality Control

Every batch of n-Arachidonoyl-L-Serine-D8 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment. Our quality assurance protocol includes advanced techniques such as NMR (¹H, ¹³C), high-resolution mass spectrometry (HRMS), and HPLC to confirm chemical and isotopic purity exceeding 98%. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, supporting research that demands traceability and reproducibility in line with ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.