Description

1H-Indole, 5-Bromo-3-[3-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-2,2-Dimethylpropyl]-2-Iodo- is a sophisticated, multi-functional indole derivative designed for advanced synthetic chemistry applications. This compound is a critical high-purity building block for medicinal chemistry and pharmaceutical research, offering versatile reactivity for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis due to its reactive bromo and iodo substituents.
• Agrochemical Development: Acts as a building block for creating new crop protection agents and pesticides with enhanced efficacy.
• Chemical Biology Probes: Employed in the development of molecular probes and labeled compounds for biochemical assays and imaging.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.
• Process Chemistry: Used in route scouting and optimization for the scalable production of complex indole-based molecules.

Basic Information

Product Name	1H-Indole, 5-Bromo-3-[3-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-2,2-Dimethylpropyl]-2-Iodo-
CAS No.	2641451-43-4
Molecular Formula	C29H33BrINOSi
Molecular Weight	670.48 g/mol
Synonyms	5-Bromo-3-[3-[(tert-Butyldiphenylsilyl)oxy]-2,2-dimethylpropyl]-2-iodo-1H-indole; 5-Bromo-2-iodo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-1H-indole; tert-Butyl((3-(5-bromo-2-iodo-1H-indol-3-yl)-2,2-dimethylpropoxy)diphenylsilane; TBDPS-protected bromo-iodo indole derivative; Advanced indole synthon; Bromo-iodo indole building block
EINECS	Contact for details

Quality Control

Our high-purity advanced intermediates are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development from milligram to kilogram scale with reliable batch-to-batch reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to maximize shelf-life. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.