Description

Cyclopenta[C]Pyrrole-2(1H)-Carboxylic Acid, Hexahydro-5-(Methylamino)-, (3Ar,6As)-Rel-, 1,1-Dimethylethyl Ester, Methanesulfonate (1:1) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and salt form. This compound is of critical importance for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers engaged in the synthesis of sophisticated drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders or other specialized therapeutic areas.
• Process Chemistry Research: Used in route scouting and optimization studies to develop efficient and scalable synthetic pathways for new chemical entities (NCEs).
• Medicinal Chemistry: Serves as a core scaffold or precursor for creating focused libraries of analogs to explore structure-activity relationships (SAR).
• GMP Manufacturing: Suitable for use in the production of clinical trial materials under controlled Good Manufacturing Practice (GMP) conditions, pending appropriate qualification.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing outsourced drug development and manufacturing services.

Basic Information

Product Name	Cyclopenta[C]Pyrrole-2(1H)-Carboxylic Acid, Hexahydro-5-(Methylamino)-, (3Ar,6As)-Rel-, 1,1-Dimethylethyl Ester, Methanesulfonate (1:1)
CAS No.	2640378-28-3
Molecular Formula	C14H26N2O5S
Molecular Weight	334.43 g/mol
Synonyms	(3Ar,6As)-rel-Hexahydro-5-(methylamino)cyclopenta[c]pyrrole-2(1H)-carboxylic acid 1,1-dimethylethyl ester methanesulfonate; tert-Butyl (3aR,6aS)-rel-hexahydro-5-(methylamino)cyclopenta[c]pyrrole-2(1H)-carboxylate methanesulfonate; rel-(3aR,6aS)-5-(Methylamino)octahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester mesylate; tert-Butyl rel-(3aR,6aS)-5-(methylamino)octahydrocyclopenta[c]pyrrole-2-carboxylate methanesulfonate; Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-(methylamino)-, (3aR,6aS)-rel-, 1,1-dimethylethyl ester, methanesulfonate; 2640378-28-3; Mesylate salt of tert-butyl hexahydro-5-(methylamino)cyclopenta[c]pyrrole-2(1H)-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality control protocols to ensure batch-to-batch consistency and reliability for critical research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development projects with customized specifications and analytical method support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if frequent access is not required. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.