Description

Methyl 5-(Dimethylphosphoryl)Pyrimidine-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrimidine core functionalized with a dimethylphosphoryl group. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel kinase inhibitors and other targeted therapeutic agents. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this specific phosphorylated heterocyclic scaffold into their molecular libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially kinase inhibitors and antiviral agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable carboxylate and phosphoryl groups.
• Agrochemical Development: Serves as a precursor in the research of novel herbicides and plant growth regulators.
• Chemical Biology Probes: Utilized in the development of molecular probes to study phosphoprotein interactions and signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring this specific phosphorylated pyrimidine derivative.
• Academic Research: Employed in university and institutional labs for fundamental studies in heterocyclic and organophosphorus chemistry.

Basic Information

Product Name	Methyl 5-(Dimethylphosphoryl)Pyrimidine-2-Carboxylate
CAS No.	2624136-36-1
Molecular Formula	C9H13N2O4P
Molecular Weight	244.18 g/mol
Synonyms	Methyl 5-(dimethylphosphoryl)pyrimidine-2-carboxylate; 5-(Dimethylphosphoryl)pyrimidine-2-carboxylic acid methyl ester; 2-Pyrimidinecarboxylic acid, 5-(dimethylphosphinyl)-, methyl ester; Methyl 5-(dimethylphosphinyl)pyrimidine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-(Dimethylphosphoryl)Pyrimidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment and opened under inert atmosphere for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.