Description

1H-Indazole, 5-Chloro-4,6-Difluoro-1-(Tetrahydro-2H-Pyran-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially in oncology and CNS-related fields.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Kinase Inhibitor Development: Serves as a core scaffold in the research and production of protein kinase inhibitors, a major class of oncology drugs.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1H-Indazole, 5-Chloro-4,6-Difluoro-1-(Tetrahydro-2H-Pyran-2-Yl)-
CAS No.	2565712-51-6
Molecular Formula	C₁₂H₁₁ClF₂N₂O
Molecular Weight	272.68 g/mol
Synonyms	5-Chloro-4,6-difluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 5-Chloro-4,6-difluoro-1-(tetrahydropyran-2-yl)-1H-indazole; 1-(Oxan-2-yl)-5-chloro-4,6-difluoro-1H-indazole; 2565712-51-6; THP-protected chloro-difluoro indazole; 5-Chloro-4,6-difluoro-1H-indazole THP ether; Indazole, 5-chloro-4,6-difluoro-1-(tetrahydro-2H-pyran-2-yl)-
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 5-Chloro-4,6-Difluoro-1-(Tetrahydro-2H-Pyran-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We support development and commercial projects with material suitable for use under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.