Description

Guanosine 5'-Triphosphate (GTP), Ammonium Salt (Ribose-3',4',5',5''-D4,98%) C.P.>90% (In Solution) is a high-purity, deuterium-labeled nucleotide essential for advanced biochemical research and diagnostic applications. This compound is critical for mechanistic studies where precise tracking of molecular pathways is required, offering researchers a powerful tool for investigating cellular energy transfer and signaling processes. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic kit manufacturers engaged in metabolomics, enzymology, and high-sensitivity assay development.

Application

• Biochemical Research & Enzymology: Used as a deuterium-labeled substrate or cofactor in kinetic studies, enzyme mechanism elucidation, and metabolic pathway tracing.
• NMR Spectroscopy & Mass Spectrometry: Serves as an internal standard or tracer in quantitative proteomics, metabolomics, and structural biology due to its stable isotopic label.
• Diagnostic Assay Development: Employed in the formulation of high-sensitivity diagnostic kits, particularly for monitoring GTPase activity or nucleotide-dependent processes.
• Pharmaceutical R&D: Facilitates drug discovery efforts targeting GTP-binding proteins (G-proteins) and related signaling cascades.
• Cell Biology & Signal Transduction Studies: Essential for research into cellular energy metabolism, protein synthesis, and receptor-mediated signaling events.

Basic Information

Item	Details
Product Name	Guanosine 5'-Triphosphate (GTP), Ammonium Salt (Ribose-3',4',5',5''-D4,98%) C.P.>90% (In Solution)
CAS No.	2483831-83-8
Molecular Formula	C10H11D4N5O14P3 · xNH3
Molecular Weight	Contact for details
Synonyms	Guanosine-5'-triphosphate ammonium salt (ribose-D4); GTP-D4 ammonium salt; [(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl tetrahydrogen triphosphate ammonium salt (ribose-3',4',5',5''-D4); Deuterated GTP; GTP (ribose-D4, 98%) ammonium salt; 5'-GTP-D4 ammonium salt; Guanosine triphosphate-D4 ammonium salt.
EINECS	Contact for details

Quality Control

Every batch of our deuterium-labeled GTP is manufactured and tested under strict quality protocols to ensure identity, purity, and isotopic enrichment. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay by HPLC, isotopic purity (D-enrichment at specified positions), and solution concentration. Our quality system is designed to support research and diagnostic applications requiring the highest levels of traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. The solution is sensitive to repeated freeze-thaw cycles and microbial contamination; aliquot aseptically for extended use. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to slightly yellow liquid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	>90% (as specified on COA)
Isotopic Purity (D-enrichment)	≥98% at Ribose-3',4',5',5'' positions
pH (in solution)	6.0 - 8.0
Solvent	Specified buffer or water (see COA)
Concentration	As specified on COA (e.g., 10 mM, 100 mM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.