Description

L-Asparagine:H2O (2,3,3-D3, 94%) is a stable isotope-labeled analog of the amino acid L-asparagine monohydrate, specifically deuterated at the 2, 3, and 3 positions with a minimum isotopic enrichment of 94%. This compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing using techniques like mass spectrometry and NMR. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors for drug development, metabolic studies, and stable isotope labeling applications. CAS No. 2483831-59-8.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the accurate quantification of L-asparagine in complex biological matrices such as plasma, urine, and tissue samples.
• Metabolic Flux Analysis (MFA): A critical tracer for studying nitrogen metabolism, amino acid biosynthesis, and cancer cell energetics in in vitro and in vivo systems.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a deuterated standard for spectral calibration and for investigating protein structure and dynamics without signal interference.
• Pharmaceutical Research & Development: Employed in the development and validation of bioanalytical methods for new drug entities, particularly those targeting amino acid metabolism.
• Nutritional Science Research: Used to trace the assimilation and utilization of asparagine in dietary and clinical nutrition studies.
• Isotope-Labeled Intermediate: Acts as a building block for the synthesis of more complex deuterated molecules for research and diagnostic purposes.

Basic Information

Product Name	L-Asparagine:H2O (2,3,3-D3, 94%)
CAS No.	2483831-59-8
Molecular Formula	C4H5D3N2O3 • H2O
Molecular Weight	154.14 g/mol (for monohydrate)
Synonyms	(2S)-2-Amino-3-carbamoylpropanoic-2,3,3-d3 acid monohydrate; L-Asparagine-2,3,3-d3 monohydrate; L-2-Aminosuccinamic-2,3,3-d3 acid monohydrate; (S)-2-Amino-3-carbamoylpropionic-2,3,3-d3 acid hydrate; Asparagine-d3 monohydrate; Deuterated L-Asparagine monohydrate
EINECS	Contact for details

Quality Control

Every batch of our L-Asparagine:H2O (2,3,3-D3, 94%) is produced and analyzed under strict quality management protocols. We guarantee the chemical purity, isotopic enrichment, and chiral integrity specified for this research-grade material. Comprehensive testing includes chiral HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, assay, isotopic purity, and related substances is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This product is hygroscopic (moisture-sensitive); keep the original container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Isotopic Enrichment	≥ 94% D (2,3,3-D3)
Optical Rotation	[α]20/D: +31° to +35° (c=2 in H2O)
Water Content (KF)	10.0% - 13.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.