Description

L-Arginine Hcl (D7) is a high-purity, deuterium-labeled derivative of the essential amino acid L-Arginine, where seven hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is critical for advanced analytical and research applications, providing unmatched precision and reliability in quantitative studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolic research, pharmacokinetics, and proteomics.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of L-Arginine levels in biological matrices.
• Pharmacokinetic and Metabolic Studies: Used in drug development to trace the absorption, distribution, metabolism, and excretion (ADME) of arginine-based therapeutics.
• Proteomics and Biomarker Research: Enables precise quantification in stable isotope labeling by amino acids in cell culture (SILAC) and other proteomic workflows.
• Clinical Diagnostics Development: Employed in the development and validation of assays for monitoring arginine-related metabolic disorders.
• Nutritional and Sports Science Research: Facilitates advanced studies on arginine metabolism, nitric oxide pathways, and athletic performance.
• Isotope Dilution Analysis: Provides high accuracy in quantifying unlabeled L-Arginine in complex samples across food, supplement, and pharmaceutical quality control.

Basic Information

Product Name	L-Arginine Hcl (D7)
CAS No.	2483830-23-3
Molecular Formula	C6H7D7ClN4O2
Molecular Weight	~ 217.7 g/mol
Synonyms	(2S)-2-Amino-5-(diaminomethylideneamino)-2,3,3,4,4,5,5-d7-pentanoic acid hydrochloride; L-Arginine-d7 hydrochloride; (S)-2-Amino-5-guanidino-d7-pentanoic acid hydrochloride; Arginine (D7) hydrochloride; L-Arg-d7 HCl; Deuterated L-Arginine HCl; Stable Isotope Labeled L-Arginine Hydrochloride
EINECS	Contact for details

Quality Control

Our L-Arginine Hcl (D7) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirming identity and absence of critical impurities. We support compliance with cGMP guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Specific Rotation	+21.0° to +23.0° (c=8 in 6N HCl)
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.