Description

5,8-Dioxa-2,11-Diazaheptadecanoic Acid, 17-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]-12,17-Dioxo-, 1,1-Dimethylethyl Ester is a sophisticated chemical building block designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists working on targeted protein degradation and novel therapeutic modalities. It is primarily utilized in the synthesis of Proteolysis-Targeting Chimeras (PROTACs) and other bifunctional molecules, serving as a key linker component that connects an E3 ligase ligand to a protein-of-interest targeting moiety.

Application

• PROTAC (Proteolysis-Targeting Chimera) Linker: A core structural component in the design and synthesis of PROTAC molecules, enabling the targeted degradation of disease-causing proteins.
• Bifunctional Molecule Synthesis: Used in the development of other heterobifunctional degraders and molecular glues for chemical biology and drug discovery.
• Pharmaceutical Intermediate: Serves as a high-value intermediate in the multi-step synthesis of preclinical and clinical-stage drug candidates.
• Chemical Biology Research: A tool compound for studying ubiquitin-proteasome system (UPS) pathways and intracellular protein regulation.
• E3 Ligase-Targeted Drug Discovery: Facilitates the creation of novel ligands and conjugates targeting specific E3 ubiquitin ligases like CRBN (Cereblon).
• Academic & Institutional R&D: Supports cutting-edge research in universities and research institutes focused on oncology, neurodegenerative diseases, and other therapeutic areas.

Basic Information

Product Name	5,8-Dioxa-2,11-Diazaheptadecanoic Acid, 17-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]-12,17-Dioxo-, 1,1-Dimethylethyl Ester
CAS No.	2435720-04-8
Molecular Formula	C35H41N5O10
Molecular Weight	691.73 g/mol
Synonyms	tert-Butyl 17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-12,17-dioxo-5,8-dioxa-2,11-diazaheptadecanoate; PROTAC Linker for CRBN; CRBN-based Degrader Linker; E3 Ligase Ligand-Linker Conjugate; (S,R,S)-AHPC-C6-NH-Boc; C6-alkyl chain linker with Boc and (S,R,S)-AHPC; Cereblon Ligand-Linker Conjugate 1; tert-Butyl (S)-4-((2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)amino)-4-oxobutyl)carbamate
EINECS	Contact for details

Quality Control

This high-purity pharmaceutical intermediate is manufactured under strict quality control protocols. Every batch is characterized and tested to ensure identity, purity, and consistency suitable for research and development applications. Certificates of Analysis (COA) are provided, detailing results from advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.