Description

Acetamide, 2-[(14-Amino-3,6,9,12-Tetraoxatetradec-1-Yl)Oxy]-n-[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]-, Hydrochloride (1:1) is a sophisticated chemical building block designed for advanced research and development. This compound is of significant interest for its role as a PROTAC (PROteolysis TArgeting Chimera) linker-payload conjugate, enabling the targeted degradation of specific proteins within cells. It is primarily utilized by pharmaceutical researchers and medicinal chemists engaged in the discovery of novel therapeutic agents, particularly in oncology and other disease areas involving protein dysregulation.

Application

• PROTAC Molecule Development: Serves as a critical component in the synthesis of Proteolysis Targeting Chimeras for targeted protein degradation therapies.
• Bioconjugation & Linker Chemistry: Used to create stable linkages between targeting ligands (like E3 ligase binders) and protein-of-interest warheads due to its integrated PEG-based linker and reactive groups.
• Oncology Research: A key intermediate in the preclinical research of anticancer drugs that operate via induced protein degradation mechanisms.
• Chemical Biology Probes: Employed in the development of tool compounds to study cellular pathways and validate novel drug targets.
• Pharmaceutical Intermediate: Acts as a high-value synthetic intermediate in the multi-step production of complex active pharmaceutical ingredients (APIs).
• Precision Medicine Platforms: Integral to research exploring novel therapeutic modalities beyond traditional small molecule inhibition.

Basic Information

Item	Details
Product Name	Acetamide, 2-[(14-Amino-3,6,9,12-Tetraoxatetradec-1-Yl)Oxy]-n-[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]-, Hydrochloride (1:1)
CAS No.	2421217-05-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker-Payload Conjugate; Thalidomide-PEG4-acid-amide-C2-NH2 hydrochloride; E3 Ligase Ligand-Linker Conjugate; (S,R,S)-AHPC-PEG4-C2-NH2.HCl; Cereblon Ligand-PEG4-amine Hydrochloride; VHL Ligand Derivative; Protein Degradation Compound Intermediate; PEGylated IMD Conjugate
EINECS	Contact for details

Quality Control

Our Acetamide, 2-[(14-Amino-3,6,9,12-Tetraoxatetradec-1-Yl)Oxy]-n-[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]-, Hydrochloride (1:1) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.