Description

1,2-Benzisoxazole, 6-Fluoro-3-(1-Nitroso-4-Piperidinyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating a benzisoxazole core, a fluorine substituent, and a nitrosopiperidine moiety. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential antipsychotic, antidepressant, or anxiolytic drug candidates targeting serotonin or dopamine receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its fluorinated benzisoxazole scaffold.
• Preclinical Drug Development: Serves as a critical precursor for producing compounds for pharmacological screening, toxicology studies, and early-stage development.
• Contract Synthesis: Supplied to CROs and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.
• Chemical Reference Standard: Utilized as an analytical standard for method development and quality control in API manufacturing processes.
• Academic Research: Employed in university and institutional labs for investigating new heterocyclic chemistry and neuropharmacology.

Basic Information

Item	Details
Product Name	1,2-Benzisoxazole, 6-Fluoro-3-(1-Nitroso-4-Piperidinyl)-
CAS No.	2416230-38-9
Molecular Formula	C12H11FN3O2
Molecular Weight	248.24 g/mol
Synonyms	6-Fluoro-3-(1-nitroso-4-piperidinyl)-1,2-benzisoxazole; 3-(1-Nitroso-4-piperidinyl)-6-fluoro-1,2-benzisoxazole; 6-Fluoro-3-(1-nitrosopiperidin-4-yl)-1,2-benzisoxazole; 1,2-Benzisoxazole, 6-fluoro-3-(1-nitroso-4-piperidinyl)-; 2416230-38-9; 6-Fluoro-3-(1-nitroso-piperidin-4-yl)-benz[d]isoxazole
EINECS	Contact for details

Quality Control

Our 1,2-Benzisoxazole, 6-Fluoro-3-(1-Nitroso-4-Piperidinyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profiles are provided with every shipment. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.