Description

2,3(1H)-Isoquinolinedicarboxylic Acid, 7-Chloro-3,4-Dihydro-, 2-(9H-Fluoren-9-Ylmethyl) Ester, (3S)- is a high-purity, advanced pharmaceutical intermediate. This compound is of significant value for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of target drug molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for API manufacturing.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective chemical transformations.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and development services.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis.

Basic Information

Item	Detail
Product Name	2,3(1H)-Isoquinolinedicarboxylic Acid, 7-Chloro-3,4-Dihydro-, 2-(9H-Fluoren-9-Ylmethyl) Ester, (3S)-
CAS No.	2411591-51-8
Molecular Formula	C26H20ClNO4
Molecular Weight	445.89 g/mol
Synonyms	(3S)-7-Chloro-2-((9H-fluoren-9-yl)methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-Fmoc-7-chloro-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-Chloro-3,4-dihydro-2,3(1H)-isoquinolinedicarboxylic acid 2-(9H-fluoren-9-ylmethyl) ester (3S)-; (3S)-7-Chloro-N-Fmoc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; CAS 2411591-51-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and MS to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Production can adhere to GMP guidelines for pharmaceutical applications as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the material should be handled in a dry environment and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.