Description

Taurodeoxycholic Acid-[D4] Sodium Salt is a high-purity, isotopically labeled derivative of the primary bile acid taurodeoxycholic acid, specifically deuterated at four positions. This compound is a critical tool for quantitative bioanalytical research, enabling precise tracking and measurement of bile acid metabolism and transport in complex biological systems. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable internal standards for mass spectrometry (LC-MS/MS).

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a quantitative reference standard for the accurate measurement of endogenous taurodeoxycholic acid and related bile acids in biological fluids (plasma, serum, bile) and tissue samples.
• Metabolic Pathway Tracing: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of bile acids and related drug candidates.
• Diagnostic Assay Development: Used in the development and validation of clinical diagnostic tests for hepatobiliary diseases, such as cholestasis, and for monitoring liver function.
• Drug Discovery & Development: Facilitates research into bile acid receptors (e.g., FXR, TGR5) and the development of therapeutics targeting metabolic and liver disorders.
• Quality Control in Pharmaceutical Manufacturing: Serves as a certified reference material (CRM) for ensuring the accuracy and consistency of analytical methods in GMP/GLP environments.
• Nutritional and Gut Microbiome Research: Applied in studies examining the interaction between diet, gut microbiota, and host bile acid metabolism.

Basic Information

Product Name	Taurodeoxycholic Acid-[D4] Sodium Salt
CAS No.	2410279-82-0
Molecular Formula	C26H40D4NNaO6S
Molecular Weight	521.70 g/mol (approx.)
Synonyms	Sodium Taurodeoxycholate-d4; 2-[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl-d4]amino]ethanesulfonate Sodium Salt; TDCA-d4 Sodium Salt; TUDCA-d4 (common abbreviation); N-(3α,12α-Dihydroxy-5β-cholan-24-oyl-d4)-taurine Sodium Salt; Deuterated Taurodeoxycholate Sodium; Taurodeoxycholic Acid (d4) Sodium Salt; Isotopically Labeled Taurodeoxycholic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Taurodeoxycholic Acid-[D4] Sodium Salt is manufactured under controlled conditions and undergoes rigorous analytical characterization to ensure identity, purity, and isotopic enrichment. Our quality assurance protocol includes advanced techniques such as NMR, HPLC, and mass spectrometry to confirm chemical and isotopic purity. A comprehensive Certificate of Analysis (COA) is supplied with each product, detailing batch-specific results for assay, isotopic purity, and related substances. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For prolonged storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (Titration)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.