Description

2,2-Difluoro-Cyclopropaneboronic Acid is a specialized organoboron building block featuring a difluorinated cyclopropane ring. This compound is valued for its unique structural motif, which imparts desirable metabolic stability and lipophilicity in advanced molecular design. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for lead optimization and the development of fluorinated analogs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a boronic acid coupling partner for the introduction of the 2,2-difluorocyclopropyl group into complex molecules.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides where the difluorocyclopropane unit can enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of advanced organic materials and liquid crystals that incorporate strained ring systems.
• Medicinal Chemistry Tool: Facilitates the exploration of structure-activity relationships (SAR) by introducing conformational constraint and fluorine atoms into target molecules.

Basic Information

Product Name	2,2-Difluoro-Cyclopropaneboronic Acid
CAS No.	2408428-30-6
Molecular Formula	C3H5BF2O2
Molecular Weight	129.88 g/mol
Synonyms	(2,2-Difluorocyclopropyl)boronic Acid; 2,2-Difluorocyclopropane-1-boronic Acid; B-(2,2-Difluorocyclopropyl)boronic Acid; 2,2-Difluorocyclopropylboronic Acid; Difluorocyclopropaneboronic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-Cyclopropaneboronic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR (1H, 13C, 19F, 11B) for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, this material should be handled and stored under an inert atmosphere (argon or nitrogen) and kept free from moisture. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.