Description

Spiro[3H-Indole-3,3'-Pyrrolidine]-1'-Carboxylic Acid, 5-Amino-1,2-Dihydro-2-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-pyrrolidine scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs targeting specific protein-protein interactions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its privileged spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional degraders.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors for cancer therapy.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Contract Development and Manufacturing (CDMO): Supplied to CDMOs for scale-up and cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Spiro[3H-Indole-3,3'-Pyrrolidine]-1'-Carboxylic Acid, 5-Amino-1,2-Dihydro-2-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	2384574-97-2
Molecular Formula	C17H21N3O3
Molecular Weight	315.37 g/mol
Synonyms	tert-Butyl 5-amino-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-1'-carboxylate; 1'-Boc-5-amino-1,2-dihydro-2-oxospiro[indole-3,3'-pyrrolidine]; 5-Amino-1,2-dihydro-2-oxospiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-5-aminooxindole-3-spiro-3'-pyrrolidine; Spiro[3H-indole-3,3'-pyrrolidine]-1'-carboxylic acid, 5-amino-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester; 5-Aminooxindole spiro-pyrrolidine Boc-protected; Boc-5-Amino-spiro-oxindole-pyrrolidine
EINECS	Contact for details

Quality Control

Our Spiro[3H-Indole-3,3'-Pyrrolidine]-1'-Carboxylic Acid, 5-Amino-1,2-Dihydro-2-Oxo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.