Description

2-Methyl-1,2,3,4-Tetrahydro-Isoquinoline-6-Boronic Acid Picol Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic acid functionality. This compound is critical for enabling key cross-coupling reactions, such as the Suzuki-Miyaura reaction, in the synthesis of complex organic molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boron-containing coupling partner for constructing biaryl and heterobiaryl structures central to many modern pharmaceuticals.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for developing new synthetic methodologies and complex molecular architectures.
• Agrochemical Development: Potential intermediate in the synthesis of advanced crop protection agents and herbicides.
• Material Science Precursor: Can be employed in the creation of organic electronic materials and ligands for catalytic systems.

Basic Information

Product Name	2-Methyl-1,2,3,4-Tetrahydro-Isoquinoline-6-Boronic Acid Picol Ester Hydrochloride
CAS No.	2379550-55-5
Molecular Formula	C₁₆H₂₁BN₂O₂ • HCl
Molecular Weight	320.62 g/mol (Free base: 284.16 g/mol)
Synonyms	2-Methyl-1,2,3,4-tetrahydroisoquinoline-6-boronic acid picol ester hydrochloride; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline HCl; 2-Methyl-1,2,3,4-Tetrahydro-6-isoquinolineboronic Acid Pinacol Ester Hydrochloride; 6-Boronic Acid Pinacol Ester-2-Methyl-1,2,3,4-tetrahydroisoquinoline Hydrochloride; MTIQ-BPin HCl; 2379550-55-5
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-1,2,3,4-Tetrahydro-Isoquinoline-6-Boronic Acid Picol Ester Hydrochloride is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.